The novel llama-human chimeric antibody has potent effect in lowering LDL-c levels in hPCSK9 transgenic rats

The novel llama-human chimeric antibody has potent effect in lowering LDL-c levels in hPCSK9 transgenic rats

Abstract Background The advent of proprotein convertase subtilisin/kexin type 9 (PCSK9)–inhibiting drugs have provided an effective, but extremely expensive treatment for the management of low density lipoprotein (LDL). Our aim was to explore a cost-effective application of camelid anti-PCSK9 single...

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Bibliographic Details
Main Authors: Xinyang Li, Meiniang Wang, Xinhua Zhang, Chuxin Liu, Haitao Xiang, Mi Huang, Yingying Ma, Xiaoyan Gao, Lin Jiang, Xiaopan Liu, Bo Li, Yong Hou, Xiuqing Zhang, Shuang Yang, Naibo Yang
Format: Article
Language:English
Published: Wiley 2020-02-01
Series:Clinical and Translational Medicine
Subjects:
PCSK9
Antibody
LDL-c
VHH-Fc
sdAb
Pichia pastoris
Online Access:http://link.springer.com/article/10.1186/s40169-020-0265-2

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http://link.springer.com/article/10.1186/s40169-020-0265-2

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