Icariin alleviates osteoarthritis through PI3K/Akt/mTOR/ULK1 signaling pathway

Icariin alleviates osteoarthritis through PI3K/Akt/mTOR/ULK1 signaling pathway

Abstract Objectives This study aims to investigate the effects of Icariin (ICA) on interleukin-1β (IL-1β)-induced osteoarthritis (OA) and its potential mechanism of action. Methods SW1353 chondrocytes were pretreated with ICA for 2 h, followed by stimulation with IL-1β to mimic OA. Expression levels...

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Bibliographic Details
Main Authors: Yan Chen, Xiaoli Pan, Jing Zhao, Chunyan Li, Yupei Lin, Yu Wang, Xu Liu, Mei Tian
Format: Article
Language:English
Published: BMC 2022-10-01
Series:European Journal of Medical Research
Subjects:
Icariin
Interleukin-1β
Autophagy
Chondrocytes
PI3K/Akt/mTOR/ULK1
Online Access:https://doi.org/10.1186/s40001-022-00820-x

Internet

https://doi.org/10.1186/s40001-022-00820-x

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