Amplified antitumor efficacy by a targeted drug retention and chemosensitization strategy-based “combo” nanoagent together with PD-L1 blockade in reversing multidrug resistance

Amplified antitumor efficacy by a targeted drug retention and chemosensitization strategy-based “combo” nanoagent together with PD-L1 blockade in reversing multidrug resistance

Abstract Background Recent studies have demonstrated that multidrug resistance (MDR) is a critical factor in the low efficacy of cancer chemotherapy. The main mechanism of MDR arises from the overexpression of P-glycoprotein (P-gp), which actively enhances drug efflux and limits the effectiveness of...

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Bibliographic Details
Main Authors: Weixi Jiang, Lei Su, Meng Ao, Xun Guo, Chen Cheng, Yuanli Luo, Zhuoyan Xie, Xingyue Wang, Junrui Wang, Shuling Liu, Yang Cao, Pan Li, Zhigang Wang, Haitao Ran, Zhiyi Zhou, Jianli Ren
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Journal of Nanobiotechnology
Subjects:
Multidrug resistance
Endo/lysosomal escape
Tumor homing-penetrating peptide
Chemotherapy enhancement
PD-L1 blockade
Online Access:https://doi.org/10.1186/s12951-021-00947-9

Internet

https://doi.org/10.1186/s12951-021-00947-9

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