Heterologous SH3-p85β inhibits influenza A virus replication

<p>Abstract</p> <p>Phosphatidylinositol 3-kinase (PI3K)/Akt signalling pathway can support the replication of influenza A virus through binding of viral NS1 protein to the Src homology 3 (SH3) domain of p85β regulatory subunit of PI3K. Here we investigated the effect of heterologou...

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Bibliographic Details
Main Authors: Chen Xiao-xuan, Zeng Xiang-xing, Zhang Chi, Zeng Jun, Su Yun, Wang Ge-fei, Li Wei-zhong, Zhang Dan-gui, Xu Yan-xuan, Li Kang-sheng
Format: Article
Language:English
Published: BMC 2010-07-01
Series:Virology Journal
Online Access:http://www.virologyj.com/content/7/1/170