Substitution of Human Papillomavirus Type 16 L2 Neutralizing Epitopes Into L1 Surface Loops: The Effect on Virus-Like Particle Assembly and Immunogenicity

Substitution of Human Papillomavirus Type 16 L2 Neutralizing Epitopes Into L1 Surface Loops: The Effect on Virus-Like Particle Assembly and Immunogenicity

Cervical cancer caused by infection with human papillomaviruses (HPVs) is the fourth most common cancer in women globally, with the burden mainly in developing countries due to limited healthcare resources. Current vaccines based on virus-like particles (VLPs) assembled from recombinant expression o...

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Bibliographic Details
Main Authors: Aleyo Chabeda, Albertha R. van Zyl, Edward P. Rybicki, Inga I. Hitzeroth
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Plant Science
Subjects:
HPV-16
L1:L2 chimera
L2 substitution
epitope display
plant-produced
cross-neutralization
Online Access:https://www.frontiersin.org/article/10.3389/fpls.2019.00779/full

Internet

https://www.frontiersin.org/article/10.3389/fpls.2019.00779/full

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