The characteristics of laboratory tests at admission and the risk factors for adverse clinical outcomes of severe and critical COVID-19 patients

Abstract Background The current coronavirus disease 2019 (COVID-19) is a public health emergency. In this study, we aimed to evaluate the risk factors for mortality in severe and critical COVID-19 patients. Methods We performed a retrospective study of patients diagnosed with severe and critical COV...

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Main Authors: Liulin Wang, Xiaobin Cheng, Qiufen Dong, Chenliang Zhou, Yeming Wang, Bin Song, Weinan Li, Min Wang, Rui Qin, Qi Long, Juan Liu, Jing Li, Dan Li, Gang Li, Yuanming Ba
Format: Article
Language:English
Published: BMC 2021-04-01
Series:BMC Infectious Diseases
Subjects:
Online Access:https://doi.org/10.1186/s12879-021-06057-z
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author Liulin Wang
Xiaobin Cheng
Qiufen Dong
Chenliang Zhou
Yeming Wang
Bin Song
Weinan Li
Min Wang
Rui Qin
Qi Long
Juan Liu
Jing Li
Dan Li
Gang Li
Yuanming Ba
author_facet Liulin Wang
Xiaobin Cheng
Qiufen Dong
Chenliang Zhou
Yeming Wang
Bin Song
Weinan Li
Min Wang
Rui Qin
Qi Long
Juan Liu
Jing Li
Dan Li
Gang Li
Yuanming Ba
author_sort Liulin Wang
collection DOAJ
description Abstract Background The current coronavirus disease 2019 (COVID-19) is a public health emergency. In this study, we aimed to evaluate the risk factors for mortality in severe and critical COVID-19 patients. Methods We performed a retrospective study of patients diagnosed with severe and critical COVID-19 from four hospitals in Wuhan, China, by evaluating the clinical characteristics and laboratory results, and using Cox proportional hazards model to assess the risk factors involved in disease progression. Results In total, 446 patients with COVID-19 were enrolled. The study indicated a high mortality rate (20.2%) in severe and critical COVID-19 patients. At the time of admission, all patients required oxygen therapy, and 52 (12%) required invasive mechanical ventilation, of which 50 (96%) died. The univariate Cox proportional hazards model showed a white blood cell count of more than 10 × 109/L (HR 3.993,95%CI 2.469 to 6.459) that correlated with an increased mortality rate. The multivariable Cox proportional hazards model demonstrated that older age (HR 1.066, 95% CI 1.043 to 1.089) and higher white blood cell count (HR 1.135, 95% CI 1.080 to 1.192) were independent risk factors for determining COVID-19 associated mortality. Conclusions COVID-19 is associated with a significant risk of morbidity and mortality in the population. Older age and higher white blood cell count were found to be independent risk factors for mortality.
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spelling doaj.art-aa628224e622414ab3bab285b36d63ce2022-12-21T23:19:15ZengBMCBMC Infectious Diseases1471-23342021-04-012111810.1186/s12879-021-06057-zThe characteristics of laboratory tests at admission and the risk factors for adverse clinical outcomes of severe and critical COVID-19 patientsLiulin Wang0Xiaobin Cheng1Qiufen Dong2Chenliang Zhou3Yeming Wang4Bin Song5Weinan Li6Min Wang7Rui Qin8Qi Long9Juan Liu10Jing Li11Dan Li12Gang Li13Yuanming Ba14Department of Critical Care Medicine, Hubei Provincial Hospital of Tranditional Chinese MedicineDepartment of Critical Care Medicine, Hubei Provincial Hospital of Tranditional Chinese MedicineDepartment of Critical Care Medicine, Hubei Provincial Hospital of Tranditional Chinese MedicineDepartment of Critical Care Medicine, Renmin Hospital of Wuhan UniversityDepartment of Critical Care Medicine, Hubei Provincial Hospital of Integrated Chinese & Western MedicineDepartment of Critical Care Medicine, Jin Yin-tan HospitalHubei Provincial Academy of Tranditional Chinese MedicineDepartment of Critical Care Medicine, Hubei Provincial Hospital of Tranditional Chinese MedicineDepartment of Critical Care Medicine, Hubei Provincial Hospital of Tranditional Chinese MedicineDepartment of Critical Care Medicine, Hubei Provincial Hospital of Tranditional Chinese MedicineDepartment of Critical Care Medicine, Hubei Provincial Hospital of Tranditional Chinese MedicineDepartment of Critical Care Medicine, Hubei Provincial Hospital of Tranditional Chinese MedicineDepartment of Critical Care Medicine, Hubei Provincial Hospital of Tranditional Chinese MedicineDepartment of Critical Care Medicine, Hubei Provincial Hospital of Tranditional Chinese MedicineHubei Provincial Academy of Tranditional Chinese MedicineAbstract Background The current coronavirus disease 2019 (COVID-19) is a public health emergency. In this study, we aimed to evaluate the risk factors for mortality in severe and critical COVID-19 patients. Methods We performed a retrospective study of patients diagnosed with severe and critical COVID-19 from four hospitals in Wuhan, China, by evaluating the clinical characteristics and laboratory results, and using Cox proportional hazards model to assess the risk factors involved in disease progression. Results In total, 446 patients with COVID-19 were enrolled. The study indicated a high mortality rate (20.2%) in severe and critical COVID-19 patients. At the time of admission, all patients required oxygen therapy, and 52 (12%) required invasive mechanical ventilation, of which 50 (96%) died. The univariate Cox proportional hazards model showed a white blood cell count of more than 10 × 109/L (HR 3.993,95%CI 2.469 to 6.459) that correlated with an increased mortality rate. The multivariable Cox proportional hazards model demonstrated that older age (HR 1.066, 95% CI 1.043 to 1.089) and higher white blood cell count (HR 1.135, 95% CI 1.080 to 1.192) were independent risk factors for determining COVID-19 associated mortality. Conclusions COVID-19 is associated with a significant risk of morbidity and mortality in the population. Older age and higher white blood cell count were found to be independent risk factors for mortality.https://doi.org/10.1186/s12879-021-06057-zCOVID-19Laboratory testsCox proportional hazards modelRisk factors
spellingShingle Liulin Wang
Xiaobin Cheng
Qiufen Dong
Chenliang Zhou
Yeming Wang
Bin Song
Weinan Li
Min Wang
Rui Qin
Qi Long
Juan Liu
Jing Li
Dan Li
Gang Li
Yuanming Ba
The characteristics of laboratory tests at admission and the risk factors for adverse clinical outcomes of severe and critical COVID-19 patients
BMC Infectious Diseases
COVID-19
Laboratory tests
Cox proportional hazards model
Risk factors
title The characteristics of laboratory tests at admission and the risk factors for adverse clinical outcomes of severe and critical COVID-19 patients
title_full The characteristics of laboratory tests at admission and the risk factors for adverse clinical outcomes of severe and critical COVID-19 patients
title_fullStr The characteristics of laboratory tests at admission and the risk factors for adverse clinical outcomes of severe and critical COVID-19 patients
title_full_unstemmed The characteristics of laboratory tests at admission and the risk factors for adverse clinical outcomes of severe and critical COVID-19 patients
title_short The characteristics of laboratory tests at admission and the risk factors for adverse clinical outcomes of severe and critical COVID-19 patients
title_sort characteristics of laboratory tests at admission and the risk factors for adverse clinical outcomes of severe and critical covid 19 patients
topic COVID-19
Laboratory tests
Cox proportional hazards model
Risk factors
url https://doi.org/10.1186/s12879-021-06057-z
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