Altered Function of the DnaJ Family Cochaperone DNJ-17 Modulates Locomotor Circuit Activity in a Caenorhabditis elegans Seizure Model

Altered Function of the DnaJ Family Cochaperone DNJ-17 Modulates Locomotor Circuit Activity in a Caenorhabditis elegans Seizure Model

The highly conserved cochaperone DnaJ/Hsp40 family proteins are known to interact with molecular chaperone Hsp70, and can regulate many cellular processes including protein folding, translocation, and degradation. In studies of Caenorhabditis elegans locomotion mutants, we identified a gain-of-funct...

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Bibliographic Details
Main Authors: Seika Takayanagi-Kiya, Yishi Jin
Format: Article
Language:English
Published: Oxford University Press 2016-07-01
Series:G3: Genes, Genomes, Genetics
Subjects:
GABA
glutamic acid decarboxylase
acetylcholine receptor
excitation
inhibition balance
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.116.028928

Internet

http://g3journal.org/lookup/doi/10.1534/g3.116.028928

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