Amine-linked diglycosides: Synthesis facilitated by the enhanced reactivity of allylic electrophiles, and glycosidase inhibition assays

Amine-linked diglycosides: Synthesis facilitated by the enhanced reactivity of allylic electrophiles, and glycosidase inhibition assays

Diglycose derivatives, consisting of two monosaccharides linked at non-anomeric positions by a bridging nitrogen atom, have been synthesised. Conversion of one of the precursor monosaccharide coupling components into an unsaturated derivative enhances its electrophilicity at the allylic position, fa...

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Bibliographic Details
Main Authors: Ian Cumpstey, Jens Frigell, Elias Pershagen, Tashfeen Akhtar, Elena Moreno-Clavijo, Inmaculada Robina, Dominic S. Alonzi, Terry D. Butters
Format: Article
Language:English
Published: Beilstein-Institut 2011-08-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
amination
glycomimetics
glycosidases
Mitsunobu
pseudodisaccharides
Online Access:https://doi.org/10.3762/bjoc.7.128

Internet

https://doi.org/10.3762/bjoc.7.128

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