Low-Dose Alkylphenol Exposure Promotes Mammary Epithelium Alterations and Transgenerational Developmental Defects, But Does Not Enhance Tumorigenic Behavior of Breast Cancer Cells

Low-Dose Alkylphenol Exposure Promotes Mammary Epithelium Alterations and Transgenerational Developmental Defects, But Does Not Enhance Tumorigenic Behavior of Breast Cancer Cells

Fetal and neonatal exposure to long-chain alkylphenols has been suspected to promote breast developmental disorders and consequently to increase breast cancer risk. However, disease predisposition from developmental exposures remains unclear. In this work, human MCF-10A mammary epithelial cells were...

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Bibliographic Details
Main Authors: Clémence Chamard-Jovenin, Charlène Thiebaut, Amand Chesnel, Emmanuel Bresso, Chloé Morel, Malika Smail-Tabbone, Marie-Dominique Devignes, Taha Boukhobza, Hélène Dumond
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Endocrinology
Subjects:
mammary gland
alkylphenol mix
cancer
development
estrogen receptor alpha 36
Online Access:http://journal.frontiersin.org/article/10.3389/fendo.2017.00272/full

Internet

http://journal.frontiersin.org/article/10.3389/fendo.2017.00272/full

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