Mining a cathepsin inhibitor library for new antiparasitic drug leads.

Mining a cathepsin inhibitor library for new antiparasitic drug leads.

The targeting of parasite cysteine proteases with small molecules is emerging as a possible approach to treat tropical parasitic diseases such as sleeping sickness, Chagas' disease, and malaria. The homology of parasite cysteine proteases to the human cathepsins suggests that inhibitors origina...

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Bibliographic Details
Main Authors: Kenny K H Ang, Joseline Ratnam, Jiri Gut, Jennifer Legac, Elizabeth Hansell, Zachary B Mackey, Katarzyna M Skrzypczynska, Anjan Debnath, Juan C Engel, Philip J Rosenthal, James H McKerrow, Michelle R Arkin, Adam R Renslo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3086806?pdf=render

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http://europepmc.org/articles/PMC3086806?pdf=render

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