Determining the contributions of protein synthesis and breakdown to muscle atrophy requires non‐steady‐state equations

Determining the contributions of protein synthesis and breakdown to muscle atrophy requires non‐steady‐state equations

Abstract Background Ageing and cachexia cause a loss of muscle mass over time, indicating that protein breakdown exceeds protein synthesis. Deuterium oxide (D2O) is used for studies of protein turnover because of the advantages of long‐term labelling, but these methods introduce considerations that...

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Bibliographic Details
Main Authors: Kamil A. Kobak, Marcus M. Lawrence, Gavin Pharaoh, Agnieszka K. Borowik, Frederick F. Peelor III, Patrick D. Shipman, Timothy M. Griffin, Holly Van Remmen, Benjamin F. Miller
Format: Article
Language:English
Published: Wiley 2021-12-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
Muscle atrophy
Denervation
Isotope labelling
Deuterium oxide
Protein synthesis
Protein degradation
Online Access:https://doi.org/10.1002/jcsm.12772

Internet

https://doi.org/10.1002/jcsm.12772

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