Beyond New Neurons in the Adult Hippocampus: Imipramine Acts as a Pro-Astrogliogenic Factor and Rescues Cognitive Impairments Induced by Stress Exposure

Beyond New Neurons in the Adult Hippocampus: Imipramine Acts as a Pro-Astrogliogenic Factor and Rescues Cognitive Impairments Induced by Stress Exposure

Depression is a prevalent, socially burdensome disease. Different studies have demonstrated the important role of astrocytes in the pathophysiology of depression as modulators of neurotransmission and neurovascular coupling. This is evidenced by astrocyte impairments observed in brains of depressed...

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Bibliographic Details
Main Authors: Ana R. Machado-Santos, Eduardo Loureiro-Campos, Patrícia Patrício, Bruna Araújo, Nuno Dinis Alves, António Mateus-Pinheiro, Joana Sofia Correia, Mónica Morais, João M. Bessa, Nuno Sousa, Ana J. Rodrigues, João Filipe Oliveira, Luísa Pinto
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cells
Subjects:
astrocytes
hippocampus
dentate gyrus
astrogliogenesis
chronic stress
antidepressants
Online Access:https://www.mdpi.com/2073-4409/11/3/390

Internet

https://www.mdpi.com/2073-4409/11/3/390

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