A CD4+ TNF+ monofunctional memory T-cell response to BCG vaccination is associated with Mycobacterium tuberculosis infection in infants exposed to HIV

A CD4+ TNF+ monofunctional memory T-cell response to BCG vaccination is associated with Mycobacterium tuberculosis infection in infants exposed to HIV

Summary: Background: The immunologic correlates of risk of Mycobacterium tuberculosis (Mtb) infection after BCG vaccination are unknown. The mechanism by which BCG influences the tuberculin skin test (TST) remains poorly understood. We evaluated CD4+ T-cell responses in infants exposed to HIV and u...

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Bibliographic Details
Main Authors: Alex J. Warr, Christine Anterasian, Javeed A Shah, Stephen C. De Rosa, Felicia K. Nguyen, Elizabeth Maleche-Obimbo, Lisa M. Cranmer, Daniel Matemo, Jerphason Mecha, John Kinuthia, Sylvia M. LaCourse, Grace C. John-Stewart, Thomas R. Hawn
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:EBioMedicine
Subjects:
Tuberculosis
BCG
HIV
T-Lymphocytes
Tuberculin test
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396422002079

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http://www.sciencedirect.com/science/article/pii/S2352396422002079

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