MUC1-C integrates aerobic glycolysis with suppression of oxidative phosphorylation in triple-negative breast cancer stem cells

MUC1-C integrates aerobic glycolysis with suppression of oxidative phosphorylation in triple-negative breast cancer stem cells

Summary: Activation of the MUC1-C protein promotes lineage plasticity, epigenetic reprogramming, and the cancer stem cell (CSC) state. The present studies performed on enriched populations of triple-negative breast cancer (TNBC) CSCs demonstrate that MUC1-C is essential for integrating activation of...

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Bibliographic Details
Main Authors: Nami Yamashita, Henry Withers, Yoshihiro Morimoto, Atrayee Bhattacharya, Naoki Haratake, Tatsuaki Daimon, Atsushi Fushimi, Ayako Nakashoji, Aaron R. Thorner, Emily Isenhart, Spencer Rosario, Mark D. Long, Donald Kufe
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:iScience
Subjects:
Molecular biology
Cell biology
Omics
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223022459

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223022459

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