Atg7 deficiency in microglia drives an altered transcriptomic profile associated with an impaired neuroinflammatory response

Atg7 deficiency in microglia drives an altered transcriptomic profile associated with an impaired neuroinflammatory response

Abstract Microglia, resident immunocompetent cells of the central nervous system, can display a range of reaction states and thereby exhibit distinct biological functions across development, adulthood and under disease conditions. Distinct gene expression profiles are reported to define each of thes...

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Bibliographic Details
Main Authors: Lara Friess, Mathilde Cheray, Lily Keane, Kathleen Grabert, Bertrand Joseph
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Molecular Brain
Subjects:
Atg7
Inflammatory response
Microglia
Neurotoxicity
NF-κB
Transcriptome
Online Access:https://doi.org/10.1186/s13041-021-00794-7

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