Reduced mitophagy is an early feature of NAFLD and liver-specific PARKIN knockout hastens the onset of steatosis, inflammation and fibrosis

Reduced mitophagy is an early feature of NAFLD and liver-specific PARKIN knockout hastens the onset of steatosis, inflammation and fibrosis

Abstract Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of pathologies that includes steatosis, steatohepatitis (NASH) and fibrosis and is strongly associated with insulin resistance and type 2 diabetes. Changes in mitochondrial function are implicated in the pathogenesis of NAFLD,...

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Bibliographic Details
Main Authors: R. Undamatla, O. G. Fagunloye, J. Chen, L. R. Edmunds, A. Murali, A. Mills, B. Xie, M. M. Pangburn, I. Sipula, G. Gibson, C. St. Croix, M. J. Jurczak
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-34710-x

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https://doi.org/10.1038/s41598-023-34710-x

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