The ApoA-I mimetic peptide 4F attenuates in vitro replication of SARS-CoV-2, associated apoptosis, oxidative stress and inflammation in epithelial cells

The ApoA-I mimetic peptide 4F attenuates in vitro replication of SARS-CoV-2, associated apoptosis, oxidative stress and inflammation in epithelial cells

An oral antiviral against SARS-CoV-2 that also attenuates inflammatory instigators of severe COVID-19 is not available to date. Herein, we show that the apoA-I mimetic peptide 4 F inhibits Spike mediated viral entry and has antiviral activity against SARS-CoV-2 in human lung epithelial Calu3 and Ver...

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Bibliographic Details
Main Authors: Theodoros Kelesidis, Madhav Sharma, Anton Petcherski, Cristelle Hugo, Ellen O’Connor, Nan W Hultgren, Eleni Ritou, David S Williams, Orian S Shirihai, Srinivasa T Reddy
Format: Article
Language:English
Published: Taylor & Francis Group 2021-12-01
Series:Virulence
Subjects:
covid-19
sars-cov-2
apoa-i mimetic peptides
4f
therapeutics
inflammation
apoptosis
antivirals
antioxidants
Online Access:http://dx.doi.org/10.1080/21505594.2021.1964329

Internet

http://dx.doi.org/10.1080/21505594.2021.1964329

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