Kindlin-1 regulates integrin dynamics and adhesion turnover.

Loss-of-function mutations in the gene encoding the integrin co-activator kindlin-1 cause Kindler syndrome. We report a novel kindlin-1-deficient keratinocyte cell line derived from a Kindler syndrome patient. Despite the expression of kindlin-2, the patient's cells display several hallmarks re...

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Bibliographic Details
Main Authors: Coert Margadant, Maaike Kreft, Giovanna Zambruno, Arnoud Sonnenberg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3679067?pdf=render