Perillaldehyde Inhibition of cGAS Reduces dsDNA-Induced Interferon Response

Perillaldehyde Inhibition of cGAS Reduces dsDNA-Induced Interferon Response

Cyclic GMP-AMP synthase (cGAS), serving as a primary sensor of intracellular DNA, is essential to initiate anti-microbial innate immunity. Inappropriate activation of cGAS by self-DNA promotes severe autoinflammatory diseases such as Aicardi–Goutières syndrome (AGS); thus, inhibition of cGAS may pro...

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Bibliographic Details
Main Authors: Lei Chu, Chenhui Li, Yongxing Li, Qiuya Yu, Huansha Yu, Chunhui Li, Wei Meng, Juanjuan Zhu, Quanyi Wang, Chen Wang, Shufang Cui
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
cyclic GMP-AMP synthase (cGAS)
perillaldehyde
herpes simplex virus type 1 (HSV-1)
innate immunity
autoimmune disease
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.655637/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.655637/full

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