Targeting PCSK9 Ameliorates Graft Vascular Disease in Mice by Inhibiting NLRP3 Inflammasome Activation in Vascular Smooth Muscle Cells

Targeting PCSK9 Ameliorates Graft Vascular Disease in Mice by Inhibiting NLRP3 Inflammasome Activation in Vascular Smooth Muscle Cells

BackgroundGraft vascular disease (GVD), which limits the long-term survival of patients after solid-organ transplantation, is associated with both immune responses and nonimmune factors, including dyslipidemia. Recent studies have shown that inhibition of proprotein convertase subtilisin/kexin type...

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Bibliographic Details
Main Authors: Yanqiang Zou, Zhang Chen, Xi Zhang, Jizhang Yu, Heng Xu, Jikai Cui, Yuan Li, Yuqing Niu, Cheng Zhou, Jiahong Xia, Jie Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
proprotein convertase subtilisin/kexin type 9
graft vascular disease
NLRP3
vascular smooth muscle cells
transplantation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.894789/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.894789/full

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