Identification of a novel sulfonamide non-nucleoside reverse transcriptase inhibitor by a phenotypic HIV-1 full replication assay.

Identification of a novel sulfonamide non-nucleoside reverse transcriptase inhibitor by a phenotypic HIV-1 full replication assay.

Classical target-based, high-throughput screening has been useful for the identification of inhibitors for known molecular mechanisms involved in the HIV life cycle. In this study, the development of a cell-based assay that uses a phenotypic drug discovery approach based on automated high-content sc...

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Bibliographic Details
Main Authors: Tae-Hee Kim, Yoonae Ko, Thierry Christophe, Jonathan Cechetto, Junwon Kim, Kyoung-Ae Kim, Annette S Boese, Jean-Michel Garcia, Denis Fenistein, Moon Kyeong Ju, Junghwan Kim, Sung-Jun Han, Ho Jeong Kwon, Vincent Brondani, Peter Sommer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3715523?pdf=render

Internet

http://europepmc.org/articles/PMC3715523?pdf=render

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