Regulation of SESAME-mediated H3T11 phosphorylation by glycolytic enzymes and metabolites.

Regulation of SESAME-mediated H3T11 phosphorylation by glycolytic enzymes and metabolites.

Cancer cells prefer aerobic glycolysis, but little is known about the underlying mechanism. Recent studies showed that the rate-limiting glycolytic enzymes, pyruvate kinase M2 (PKM2) directly phosphorylates H3 at threonine 11 (H3T11) to regulate gene expression and cell proliferation, revealing its...

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Bibliografiska uppgifter
Huvudupphovsmän: Qi Yu, Chong Tong, Mingdan Luo, Xiangyan Xue, Qianyun Mei, Lixin Ma, Xiaolan Yu, Wuxiang Mao, Lingbao Kong, Xilan Yu, Shanshan Li
Materialtyp: Artikel
Språk:English
Publicerad: Public Library of Science (PLoS) 2017-01-01
Serie:PLoS ONE
Länkar:http://europepmc.org/articles/PMC5398556?pdf=render

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http://europepmc.org/articles/PMC5398556?pdf=render

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