SU16f inhibits fibrotic scar formation and facilitates axon regeneration and locomotor function recovery after spinal cord injury by blocking the PDGFRβ pathway

SU16f inhibits fibrotic scar formation and facilitates axon regeneration and locomotor function recovery after spinal cord injury by blocking the PDGFRβ pathway

Abstract Background Excessively deposited fibrotic scar after spinal cord injury (SCI) inhibits axon regeneration. It has been reported that platelet-derived growth factor receptor beta (PDGFRβ), as a marker of fibrotic scar-forming fibroblasts, can only be activated by platelet-derived growth facto...

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Bibliographic Details
Main Authors: Ziyu Li, Shuisheng Yu, Yanchang Liu, Xuyang Hu, Yiteng Li, Zhaoming Xiao, Yihao Chen, Dasheng Tian, Xinzhong Xu, Li Cheng, Meige Zheng, Juehua Jing
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Journal of Neuroinflammation
Subjects:
Spinal cord injury
Fibrotic scar
PDGFRβ
Platelet-derived growth factor
SU16f
Online Access:https://doi.org/10.1186/s12974-022-02449-3

Internet

https://doi.org/10.1186/s12974-022-02449-3

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