Qingfei Jiedu decoction inhibits PD-L1 expression in lung adenocarcinoma based on network pharmacology analysis, molecular docking and experimental verification

Qingfei Jiedu decoction inhibits PD-L1 expression in lung adenocarcinoma based on network pharmacology analysis, molecular docking and experimental verification

Objective: We aim at investigating the molecular mechanisms through which the Qingfei Jiedu decoction (QFJDD) regulates PD-L1 expression in lung adenocarcinoma (LUAD).Methods: Bioactive compounds and targets of QFJDD were screened from TCMSP, BATMAN-TCM, and literature. Then, GeneCard, OMIM, PharmGK...

Full description

Bibliographic Details
Main Authors: Junjie Pan, Hongkuan Yang, Lihong Zhu, Yafang Lou, Bo Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Pharmacology
Subjects:
Qingfei Jiedu decoction
lung adenocarcinoma
programmed cell death ligand-1
CD8+PD-1+T
network pharmacology
molecular docking
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.897966/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.897966/full

Similar Items