Thailandepsins are new small molecule class I HDAC inhibitors with potent cytotoxic activity in ovarian cancer cells: a preclinical study of epigenetic ovarian cancer therapy

Thailandepsins are new small molecule class I HDAC inhibitors with potent cytotoxic activity in ovarian cancer cells: a preclinical study of epigenetic ovarian cancer therapy

<p>Abstract</p> <p>Background</p> <p>New treatment strategies are emerging to target DNA damage response pathways in ovarian cancer. Our group has previously shown that the class I biased HDAC inhibitor romidepsin (FK228) induces DNA damage response and has potent cytot...

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Bibliographic Details
Main Authors: Wilson Andrew J, Cheng Yi-Qiang, Khabele Dineo
Format: Article
Language:English
Published: BMC 2012-04-01
Series:Journal of Ovarian Research
Subjects:
HDAC inhibitors
Thailandepsins
Romidepsin
Ovarian cancer
Online Access:http://www.ovarianresearch.com/content/5/1/12

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