The Correlation Between Busulfan Exposure and Clinical Outcomes in Chinese Pediatric Patients: A Population Pharmacokinetic Study

The Correlation Between Busulfan Exposure and Clinical Outcomes in Chinese Pediatric Patients: A Population Pharmacokinetic Study

Aims: The aims of the study were to 1) establish a population pharmacokinetic (Pop-PK) model for busulfan in Chinese pediatric patients undergoing hematopoietic stem cell transplantation (HSCT) and then estimate busulfan exposure and 2) explore the association between busulfan exposure and clinical...

Full description

Bibliographic Details
Main Authors: Xiaohuan Du, Chenrong Huang, Ling Xue, Zheng Jiao, Min Zhu, Jie Li, Jun Lu, Peifang Xiao, Xuemei Zhou, Chenmei Mao, Zengyan Zhu, Ji Dong, Xiaoxue Liu, Zhiyao Chen, Shichao Zhang, Yiduo Ding, Shaoyan Hu, Liyan Miao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
event-free survival
busulfan exposure
population pharmacokinetics
pediatric patients
hematopoietic stem cell transplantation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.905879/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.905879/full

Similar Items