Tnfrsf4-expressing regulatory T cells promote immune escape of chronic myeloid leukemia stem cells

Tnfrsf4-expressing regulatory T cells promote immune escape of chronic myeloid leukemia stem cells

Leukemia stem cells (LSCs) promote the disease and seem resistant to therapy and immune control. Why LSCs are selectively resistant against elimination by CD8+ cytotoxic T cells (CTLs) is still unknown. In this study, we demonstrate that LSCs in chronic myeloid leukemia (CML) can be recognized and k...

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Bibliographic Details
Main Authors: Magdalena Hinterbrandner, Viviana Rubino, Carina Stoll, Stefan Forster, Noah Schnüriger, Ramin Radpour, Gabriela M. Baerlocher, Adrian F. Ochsenbein, Carsten Riether
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-12-01
Series:JCI Insight
Subjects:
Hematology
Stem cells
Online Access:https://doi.org/10.1172/jci.insight.151797

Internet

https://doi.org/10.1172/jci.insight.151797

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