Molecular interactions between a diphenyl scaffold and PED/PEA15: Implications for type II diabetes therapeutics targeting PED/PEA15 – Phospholipase D1 interaction

Molecular interactions between a diphenyl scaffold and PED/PEA15: Implications for type II diabetes therapeutics targeting PED/PEA15 – Phospholipase D1 interaction

In a recent study, we have identified BPH03 as a promising scaffold for the development of compounds aimed at modulating the interaction between PED/PEA15 (Phosphoprotein Enriched in Diabetes/Phosphoprotein Enriched in Astrocytes 15) and PLD1 (phospholipase D1), with potential applications in type I...

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Bibliographic Details
Main Authors: Ivan Mercurio, Gianluca D’Abrosca, Maria della Valle, Gaetano Malgieri, Roberto Fattorusso, Carla Isernia, Luigi Russo, Sonia Di Gaetano, Emilia Maria Pedone, Luciano Pirone, Annarita Del Gatto, Laura Zaccaro, Domenico Alberga, Michele Saviano, Giuseppe Felice Mangiatordi
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Phosphoprotein Enriched in Diabetes/Phosphoprotein Enriched in Astrocytes 15
Type II diabetes
Molecular Dynamics
Cavity mapping
Nuclear Magnetic Resonance
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037024001466

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http://www.sciencedirect.com/science/article/pii/S2001037024001466

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