Manipulation of PD‐L1 Endosomal Trafficking Promotes Anticancer Immunity

Manipulation of PD‐L1 Endosomal Trafficking Promotes Anticancer Immunity

Abstract The aberrant regulation of PD‐L1 in tumor cells remains poorly understood. Here, the authors systematically investigate the endosomal trafficking of plasma membrane PD‐L1 in tumor cells. They show that plasma membrane PD‐L1 is continuously internalized, and then trafficked from early endoso...

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Bibliographic Details
Main Authors: Zuodong Ye, Yiding Xiong, Wang Peng, Wenjie Wei, Lihong Huang, Juliana Yue, Chunyuan Zhang, Ge Lin, Feng Huang, Liang Zhang, Songguo Zheng, Jianbo Yue
Format: Article
Language:English
Published: Wiley 2023-02-01
Series:Advanced Science
Subjects:
6J1
anticancer immunity
endocytosis
endosomal trafficking
extracellular vesicle
PD‐L1
Online Access:https://doi.org/10.1002/advs.202206411

Internet

https://doi.org/10.1002/advs.202206411

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