BDNF-Related Imbalance of Copine 6 and Synaptic Plasticity Markers Couples With Depression-Like Behavior and Immune Activation in CUMS Rats

BDNF-Related Imbalance of Copine 6 and Synaptic Plasticity Markers Couples With Depression-Like Behavior and Immune Activation in CUMS Rats

Chronic stress is a contributing risk factor in the pathogenesis of depression. Although the mechanisms are multifaceted, the relationship can be ascribed partly to stress-related alterations in immune activation and brain plasticity. Considering the increasing evidence regarding the role of Copine...

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Bibliographic Details
Main Authors: Yin-xiu Han, Chen Tao, Xin-ran Gao, Le-le Wang, Fu-hao Jiang, Chong Wang, Ke Fang, Xing-xing Chen, Zheng Chen, Jin-fang Ge
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Neuroscience
Subjects:
depression
chronic unpredictable mild stress (CUMS)
saccharin preference
Copine 6
BDNF
synaptotagmin I
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00731/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2018.00731/full

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