Transcription shapes DNA replication initiation to preserve genome integrity

Transcription shapes DNA replication initiation to preserve genome integrity

Abstract Background Early DNA replication occurs within actively transcribed chromatin compartments in mammalian cells, raising the immediate question of how early DNA replication coordinates with transcription to avoid collisions and DNA damage. Results We develop a high-throughput nucleoside analo...

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Bibliographic Details
Main Authors: Yang Liu, Chen Ai, Tingting Gan, Jinchun Wu, Yongpeng Jiang, Xuhao Liu, Rusen Lu, Ning Gao, Qing Li, Xiong Ji, Jiazhi Hu
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Genome Biology
Subjects:
DNA replication initiation
Transcription
MCM redistribution
Transcription-replication initiation collision
Genome instability
DNA damage
Online Access:https://doi.org/10.1186/s13059-021-02390-3

Internet

https://doi.org/10.1186/s13059-021-02390-3

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