A Modified Bacillus Calmette-Guérin (BCG) Vaccine with Reduced Activity of Antioxidants and Glutamine Synthetase Exhibits Enhanced Protection of Mice despite Diminished in Vivo Persistence

A Modified Bacillus Calmette-Guérin (BCG) Vaccine with Reduced Activity of Antioxidants and Glutamine Synthetase Exhibits Enhanced Protection of Mice despite Diminished in Vivo Persistence

Early attempts to improve BCG have focused on increasing the expression of prominent antigens and adding recombinant toxins or cytokines to influence antigen presentation. One such modified BCG vaccine candidate has been withdrawn from human clinical trials due to adverse effects. BCG was derived fr...

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Bibliographic Details
Main Authors: Douglas S. Kernodle, Michael H. Cynamon, Hiriam O. Gates, Alexandria D. Allen, Miriam Braunstein, Kyi-Toe Tham, Carolyn M. Shoen, Michelle S. DeStefano, Cynthia C. Hager
Format: Article
Language:English
Published: MDPI AG 2013-01-01
Series:Vaccines
Subjects:
tuberculosis
vaccine
Bacillus Calmette-Guérin (BCG)
antioxidants
superoxide dismutase
sigma factor
glutamine synthetase
immunity
immune suppression
Online Access:http://www.mdpi.com/2076-393X/1/1/34

Internet

http://www.mdpi.com/2076-393X/1/1/34

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