The proton-pump inhibitor lansoprazole enhances amyloid beta production.

A key event in the pathogenesis of Alzheimer's disease (AD) is the accumulation of amyloid-β (Aβ) species in the brain, derived from the sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretases. Based on a systems biology study to repurpose drugs for AD, we explore the...

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Bibliographic Details
Main Authors: Nahuai Badiola, Victor Alcalde, Albert Pujol, Lisa-Marie Münter, Gerd Multhaup, Alberto Lleó, Mireia Coma, Montserrat Soler-López, Patrick Aloy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23520537/?tool=EBI