Metronomic cyclophosphamide and metformin inhibited tumor growth and repopulated tumor-infiltrating lymphocytes in an experimental carcinoma model

Metronomic cyclophosphamide and metformin inhibited tumor growth and repopulated tumor-infiltrating lymphocytes in an experimental carcinoma model

Abstract Metformin is a widely used antidiabetic biguanide. Retrospective data demonstrated the association of metformin use with survival benefit in multiple tumor types. Interest in repurposing metformin to treat cancer has not been translated into encouraging clinical benefit. In animal models, m...

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Bibliographic Details
Main Authors: Heba Mohamed Zaki, Khadiga Mohamed Ali, Mona Younis Youssef Abd Allah, Amoura Mohamed Abouelnaga, Mohamed Elsaid Abdraboh, Osama Hussein
Format: Article
Language:English
Published: BMC 2024-01-01
Series:BMC Research Notes
Subjects:
Metformin
Metronomic therapy
Tumor infiltrating lymphocytes
Animal model
Online Access:https://doi.org/10.1186/s13104-023-06651-1

Internet

https://doi.org/10.1186/s13104-023-06651-1

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