Cholestasis alters brain lipid and bile acid composition and compromises motor function in neonatal piglets

Cholestasis alters brain lipid and bile acid composition and compromises motor function in neonatal piglets

Abstract Infants with neonatal cholestasis are prone to neurodevelopmental deficits, however, the underlying pathogenesis is unclear. Lipid malabsorption and accumulation of potentially neurotoxic molecules in the blood such as bile acids are important yet relatively unexplored pathways. Here, we de...

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Bibliographic Details
Main Authors: Nicole Lind Henriksen, Svend Høime Hansen, Matthew Domenic Lycas, Xiaoyu Pan, Thomas Eriksen, Lars Søndergaard Johansen, Richard R. Sprenger, Christer Stenby Ejsing, Douglas G. Burrin, Kerstin Skovgaard, Vibeke Brix Christensen, Thomas Thymann, Stanislava Pankratova
Format: Article
Language:English
Published: Wiley 2022-07-01
Series:Physiological Reports
Subjects:
bile acids
brain
cholestasis
lipids
motor skills
Online Access:https://doi.org/10.14814/phy2.15368

Internet

https://doi.org/10.14814/phy2.15368

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