Application of the RBBP9 Serine Hydrolase Inhibitor, ML114, Decouples Human Pluripotent Stem Cell Proliferation and Differentiation

Application of the RBBP9 Serine Hydrolase Inhibitor, ML114, Decouples Human Pluripotent Stem Cell Proliferation and Differentiation

Retinoblastoma binding protein 9 (RBBP9) is required for maintaining the expression of both pluripotency and cell cycle genes in human pluripotent stem cells (hPSCs). An siRNA-based study from our group showed it does so by influencing cell cycle progression through the RB/E2F pathway. In non-plurip...

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Bibliographic Details
Main Authors: Seakcheng Lim, Rachel A. Shparberg, Jens R. Coorssen, Michael D. O’Connor
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
human pluripotent stem cells
ML114
NFYA
pluripotency
proliferation
RBBP9
Online Access:https://www.mdpi.com/1422-0067/21/23/8983

Internet

https://www.mdpi.com/1422-0067/21/23/8983

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