Sperm morphological abnormalities in autosomal dominant polycystic kidney disease are associated with the Hippo signaling pathway via PC1

Sperm morphological abnormalities in autosomal dominant polycystic kidney disease are associated with the Hippo signaling pathway via PC1

BackgroundAutosomal dominant polycystic kidney disease (ADPKD) is a hereditary kidney disorder mostly caused by mutations in PKD1 or PKD2 genes. Here, we report thirteen ADPKD males with infertility and investigated the sperm morphological defects associated with PC1 disruption.MethodsTargeted next-...

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Bibliographic Details
Main Authors: Wei-Hui Shi, Zhi-Yang Zhou, Mu-Jin Ye, Ning-Xin Qin, Zi-Ru Jiang, Xuan-You Zhou, Nai-Xin Xu, Xian-Lin Cao, Song-Chang Chen, He-Feng Huang, Chen-Ming Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Endocrinology
Subjects:
autosomal dominant polycystic kidney disease
PKD1
male infertility
sperm flagella
the Hippo pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1130536/full

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https://www.frontiersin.org/articles/10.3389/fendo.2023.1130536/full

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