Ambroxol-Enhanced Frequency and Amplitude of Beating Cilia Controlled by a Voltage-Gated Ca<sup>2+</sup> Channel, Cav1.2, via pH<sub>i</sub> Increase and [Cl<sup>−</sup>]<sub>i</sub> Decrease in the Lung Airway Epithelial Cells of Mice

Ambroxol-Enhanced Frequency and Amplitude of Beating Cilia Controlled by a Voltage-Gated Ca<sup>2+</sup> Channel, Cav1.2, via pH<sub>i</sub> Increase and [Cl<sup>−</sup>]<sub>i</sub> Decrease in the Lung Airway Epithelial Cells of Mice

Ambroxol (ABX), a frequently prescribed secretolytic agent which enhances the ciliary beat frequency (CBF) and ciliary bend angle (CBA, an index of amplitude) by 30%, activates a voltage-dependent Ca<sup>2+</sup> channel (Ca<sub>V</sub>1.2) and a small transient Ca<sup>...

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Bibliographic Details
Main Authors: Takashi Nakahari, Chihiro Suzuki, Kotoku Kawaguchi, Shigekuni Hosogi, Saori Tanaka, Shinji Asano, Toshio Inui, Yoshinori Marunaka
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:International Journal of Molecular Sciences
Subjects:
voltage-gated Ca<sup>2+</sup> channels
[Ca<sup>2+</sup>]<sub>i</sub>
intracellular pH
intracellular Cl<sup>−</sup> concentration
cell volume
Ca<sub>V</sub>1.2
Online Access:https://www.mdpi.com/1422-0067/24/23/16976

Internet

https://www.mdpi.com/1422-0067/24/23/16976

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