An obligatory role of mind bomb-1 in notch signaling of mammalian development.
The Notch signaling pathway is an evolutionarily conserved intercellular signaling module essential for cell fate specification that requires endocytosis of Notch ligands. Structurally distinct E3 ubiquitin ligases, Neuralized (Neur) and Mind bomb (Mib), cooperatively regulate the endocytosis of Not...
Main Authors: | , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2007-11-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC2082076?pdf=render |