Integration of single-cell and bulk RNA-seq to establish a predictive signature based on the differentiation trajectory of M2 macrophages in lung adenocarcinoma

Integration of single-cell and bulk RNA-seq to establish a predictive signature based on the differentiation trajectory of M2 macrophages in lung adenocarcinoma

Background: Tumor-associated macrophages as important members of the tumor microenvironment, are highly plastic and heterogeneous. TAMs can be classified into two preliminary subtypes: M1 and M2 macrophages. M2 macrophages are significantly associated with the progression of lung adenocarcinoma. How...

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Bibliographic Details
Main Authors: Zhike Chen, Jian Yang, Yu Li, Weibiao Zeng, Yiling Bai, Cheng Ding, Chun Xu, Chang Li, Jun Chen, Sheng Ju, Lijuan Tang, Jun Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Genetics
Subjects:
lung adenocarcinoma
tumor microenvironment (TME)
M2 macrophages
ScRNA-seq
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.1010440/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2022.1010440/full

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