Synthesis of C2-Alkoxy-Substituted 19-Nor Vitamin D<sub>3</sub> Derivatives: Stereoselectivity and Biological Activity

Synthesis of C2-Alkoxy-Substituted 19-Nor Vitamin D<sub>3</sub> Derivatives: Stereoselectivity and Biological Activity

The active form of vitamin D<sub>3</sub> (D<sub>3</sub>), 1a,25-dihydroxyvitamn D<sub>3</sub> (1,25D<sub>3</sub>), plays a central role in calcium and bone metabolism. Many structure–activity relationship (SAR) studies of D<sub>3</sub> have...

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Bibliographic Details
Main Authors: Yuka Mizumoto, Ryota Sakamoto, Akiko Nagata, Suzuka Sakane, Atsushi Kittaka, Minami Odagi, Masayuki Tera, Kazuo Nagasawa
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Biomolecules
Subjects:
C2-substitution
19-norvitamin D<sub>3</sub>
Julia olefination
stereoselectivity
VDR binding affinity
cell differentiation
Online Access:https://www.mdpi.com/2218-273X/12/1/69

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https://www.mdpi.com/2218-273X/12/1/69

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