Kinetics of α-synuclein prions preceding neuropathological inclusions in multiple system atrophy.

Kinetics of α-synuclein prions preceding neuropathological inclusions in multiple system atrophy.

Multiple system atrophy (MSA), a progressive neurodegenerative disease characterized by autonomic dysfunction and motor impairment, is caused by the self-templated misfolding of the protein α-synuclein. With no treatment currently available, we sought to characterize the spread of α-synuclein in a t...

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Bibliographic Details
Main Authors: Amanda L Woerman, Smita Patel, Sabeen A Kazmi, Abby Oehler, Jisoo Lee, Daniel A Mordes, Steven H Olson, Stanley B Prusiner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-02-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008222

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https://doi.org/10.1371/journal.ppat.1008222

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