Calsyntenin-1 Negatively Regulates ICAM5 Accumulation in Postsynaptic Membrane and Influences Dendritic Spine Maturation in a Mouse Model of Fragile X Syndrome

Calsyntenin-1 Negatively Regulates ICAM5 Accumulation in Postsynaptic Membrane and Influences Dendritic Spine Maturation in a Mouse Model of Fragile X Syndrome

Fragile X syndrome (FXS) is a neurodevelopmental disorder that causes intellectual disability, as well as the leading monogenic cause of autism spectrum disorders (ASD), in which neurons show aberrant dendritic spine structure. The reduction/absence of the functional FMRP protein, coded by the X-lin...

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Bibliographic Details
Main Authors: Ke Cheng, Yu-shan Chen, Chao-xiong Yue, Si-ming Zhang, Ya-Ping Pei, Gui-rong Cheng, Dan Liu, Lang Xu, Hong-xin Dong, Yan Zeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Neuroscience
Subjects:
calsyntenin-1 (CLSTN1)
intercellular adhesion molecule-5 (ICAM5)
dendritic spine
intracellular transport
fragile X syndrome
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.01098/full

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https://www.frontiersin.org/article/10.3389/fnins.2019.01098/full

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