GSK3β-mediated tau hyperphosphorylation triggers diabetic retinal neurodegeneration by disrupting synaptic and mitochondrial functions

GSK3β-mediated tau hyperphosphorylation triggers diabetic retinal neurodegeneration by disrupting synaptic and mitochondrial functions

Abstract Background Although diabetic retinopathy (DR) has long been considered as a microvascular disorder, mounting evidence suggests that diabetic retinal neurodegeneration, in particular synaptic loss and dysfunction of retinal ganglion cells (RGCs) may precede retinal microvascular changes. Key...

Full description

Bibliographic Details
Main Authors: Huazhang Zhu, Weizhen Zhang, Yingying Zhao, Xingsheng Shu, Wencong Wang, Dandan Wang, Yangfan Yang, Zhijun He, Xiaomei Wang, Ying Ying
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Molecular Neurodegeneration
Subjects:
Diabetic retinopathy
Retinal neurodegeneration
Retinal ganglion cells
Hyperphosphorylated tau
GSK3β
Synaptic and mitochondrial dysfunction
Online Access:http://link.springer.com/article/10.1186/s13024-018-0295-z

Internet

http://link.springer.com/article/10.1186/s13024-018-0295-z

Similar Items