A Dietary Supplement Containing Fucoidan Preserves Endothelial Glycocalyx through ERK/MAPK Signaling and Protects against Damage Induced by CKD Serum

A Dietary Supplement Containing Fucoidan Preserves Endothelial Glycocalyx through ERK/MAPK Signaling and Protects against Damage Induced by CKD Serum

(1) Damage to the endothelial glycocalyx (eGC), a protective layer lining the endothelial luminal surface, is associated with chronic kidney disease (CKD), which leads to a worsening of cardiovascular outcomes in these patients. Currently, there are no targeted therapeutic approaches. Whether the di...

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Bibliographic Details
Main Authors: Manuel Regier, Carolin Christina Drost, Matthias Rauen, Hermann Pavenstädt, Alexandros Rovas, Philipp Kümpers, Hans Vink, Robert M. Long, Wolfgang A. Linke, Jerzy-Roch Nofer, Alexander-Henrik Lukasz
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
endothelial activation
glycocalyx
fucoidan
ERK/MAPK signaling
endocalyx
chronic kidney disease
Online Access:https://www.mdpi.com/1422-0067/23/24/15520

Internet

https://www.mdpi.com/1422-0067/23/24/15520

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