Transgenic Overexpression of Myocilin Leads to Variable Ocular Anterior Segment and Retinal Alterations Associated with Extracellular Matrix Abnormalities in Adult Zebrafish

Transgenic Overexpression of Myocilin Leads to Variable Ocular Anterior Segment and Retinal Alterations Associated with Extracellular Matrix Abnormalities in Adult Zebrafish

Myocilin is an enigmatic glaucoma-associated glycoprotein whose biological role remains incompletely understood. To gain novel insight into its normal function, we used transposon-mediated transgenesis to generate the first zebrafish line stably overexpressing myocilin [Tg(actb1:myoc-2A-mCherry)]. q...

Full description

Bibliographic Details
Main Authors: Raquel Atienzar-Aroca, Jesús-José Ferre-Fernández, Angel Tevar, Juan-Manuel Bonet-Fernández, María-José Cabañero, María-José Ruiz-Pastor, Nicolás Cuenca, José-Daniel Aroca-Aguilar, Julio Escribano
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
myocilin
myoc
zebrafish
transgenic myoc
anterior segment alterations
retinal dysplasia
Online Access:https://www.mdpi.com/1422-0067/23/17/9989

Internet

https://www.mdpi.com/1422-0067/23/17/9989

Similar Items