Endoplasmic Reticulum Associated Aminopeptidase 2 (ERAP2) Is Released in the Secretome of Activated MDMs and Reduces in vitro HIV-1 Infection

Endoplasmic Reticulum Associated Aminopeptidase 2 (ERAP2) Is Released in the Secretome of Activated MDMs and Reduces in vitro HIV-1 Infection

Background: Haplotype-specific alternative splicing of the endoplasmic reticulum (ER) aminopeptidase type 2 (ERAP2) gene results in either full-length (FL, haplotype A) or alternatively spliced (AS, haplotype B) mRNA. HapA/HapA homozygous (HomoA) subjects show a reduced susceptibility to HIV-1 infec...

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Bibliographic Details
Main Authors: Irma Saulle, Salomè Valentina Ibba, Enrica Torretta, Cecilia Vittori, Claudio Fenizia, Federica Piancone, Davide Minisci, Elisa Maria Lori, Daria Trabattoni, Cecilia Gelfi, Mario Clerici, Mara Biasin
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
ERAP2
haplotype
HIV-1
MDM
secretion
immune system
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01648/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01648/full

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