Streptococcus pneumoniae in biofilms are unable to cause invasive disease due to altered virulence determinant production.

It is unclear whether Streptococcus pneumoniae in biofilms are virulent and contribute to development of invasive pneumococcal disease (IPD). Using electron microscopy we confirmed the development of mature pneumococcal biofilms in a continuous-flow-through line model and determined that biofilm for...

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Bibliographic Details
Main Authors: Carlos J Sanchez, Nikhil Kumar, Anel Lizcano, Pooja Shivshankar, Julie C Dunning Hotopp, James H Jorgensen, Hervé Tettelin, Carlos J Orihuela
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3234282?pdf=render