Chronic Caffeine Treatment Protects Against α-Synucleinopathy by Reestablishing Autophagy Activity in the Mouse Striatum

Chronic Caffeine Treatment Protects Against α-Synucleinopathy by Reestablishing Autophagy Activity in the Mouse Striatum

Despite converging epidemiological evidence for the inverse relationship of regular caffeine consumption and risk of developing Parkinson's disease (PD) with animal studies demonstrating protective effect of caffeine in various neurotoxin models of PD, whether caffeine can protect against mutan...

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Bibliographic Details
Main Authors: Yanan Luan, Xiangpeng Ren, Wu Zheng, Zhenhai Zeng, Yingzi Guo, Zhidong Hou, Wei Guo, Xingjun Chen, Fei Li, Jiang-Fan Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Neuroscience
Subjects:
α-synuclein
caffeine
autophagy
macroautophagy
α-synucleinopathy
Parkinson's disease
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2018.00301/full

Internet

http://journal.frontiersin.org/article/10.3389/fnins.2018.00301/full

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