Engineering the 2-Oxoglutarate Dehydrogenase Complex to Understand Catalysis and Alter Substrate Recognition

Engineering the 2-Oxoglutarate Dehydrogenase Complex to Understand Catalysis and Alter Substrate Recognition

The <i>E. coli</i> 2-oxoglutarate dehydrogenase complex (OGDHc) is a multienzyme complex in the tricarboxylic acid cycle, consisting of multiple copies of three components, 2-oxoglutarate dehydrogenase (E1o), dihydrolipoamide succinyltransferase (E2o) and dihydrolipoamide dehydrogenase (...

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Bibliographic Details
Main Authors: Joydeep Chakraborty, Natalia Nemeria, Yujeong Shim, Xu Zhang, Elena L. Guevara, Hetal Patel, Edgardo T. Farinas, Frank Jordan
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Reactions
Subjects:
multienzyme complex
site saturation mutagenesis
catalysis
thiamin diphosphate
chemoenzymatic synthesis
carboligation
Online Access:https://www.mdpi.com/2624-781X/3/1/11

Internet

https://www.mdpi.com/2624-781X/3/1/11

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